Romero-Rodríguez Alba, Rocha Diana, Ruiz-Villafán Beatriz, Guzmán-Trampe Silvia, Maldonado-Carmona Nidia, Vázquez-Hernández Melissa, Zelarayán Augusto, Rodríguez-Sanoja Romina, Sánchez Sergio
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Tercer Circuito Exterior de Ciudad Universitaria, Mexico City, 04510, Mexico.
World J Microbiol Biotechnol. 2017 Sep;33(9):162. doi: 10.1007/s11274-017-2328-0. Epub 2017 Aug 2.
One of the most significant control mechanisms of the physiological processes in the genus Streptomyces is carbon catabolite repression (CCR). This mechanism controls the expression of genes involved in the uptake and utilization of alternative carbon sources in Streptomyces and is mostly independent of the phosphoenolpyruvate phosphotransferase system (PTS). CCR also affects morphological differentiation and the synthesis of secondary metabolites, although not all secondary metabolite genes are equally sensitive to the control by the carbon source. Even when the outcome effect of CCR in bacteria is the same, their essential mechanisms can be rather different. Although usually, glucose elicits this phenomenon, other rapidly metabolized carbon sources can also cause CCR. Multiple efforts have been put through to the understanding of the mechanism of CCR in this genus. However, a reasonable mechanism to explain the nature of this process in Streptomyces does not yet exist. Several examples of primary and secondary metabolites subject to CCR will be examined in this review. Additionally, recent advances in the metabolites and protein factors involved in the Streptomyces CCR, as well as their mechanisms will be described and discussed in this review.
在链霉菌属中，碳分解代谢物阻遏（CCR）是生理过程最重要的控制机制之一。该机制控制着链霉菌中与替代碳源摄取和利用相关基因的表达，并且大多独立于磷酸烯醇式丙酮酸磷酸转移酶系统（PTS）。CCR还影响形态分化和次级代谢产物的合成，尽管并非所有次级代谢产物基因对碳源控制的敏感程度都相同。即使CCR在细菌中的最终效应相同，其基本机制也可能大不相同。虽然通常是葡萄糖引发这种现象，但其他快速代谢的碳源也可导致CCR。人们为了解链霉菌属中CCR的机制付出了诸多努力。然而，尚无合理机制来解释链霉菌中这一过程的本质。本综述将研究一些受CCR调控的初级和次级代谢产物实例。此外，本综述还将描述和讨论链霉菌CCR中涉及的代谢产物和蛋白质因子的最新进展及其机制。
