Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Curr Hypertens Rep. 2017 Sep;19(9):69. doi: 10.1007/s11906-017-0770-x.
Uric acid is the final oxidation product of purine metabolism in circulation and has been associated with the occurrence of gout and kidney stones. Type 2 diabetes mellitus and hypertension are two important public health challenges, and both are linked to increased risk of cardiovascular events. Hyperuricemia has recently emerged as an independent risk factor in the development of type 2 diabetes mellitus and hypertension through several proposed mechanisms. Few clinical trials investigated the use of uric acid lowering agents in the management of these two disease entities; however, their results provided encouraging evidence to a potential role for these agents in fighting disease burden. Larger randomized controlled trials are therefore warranted to establish the role of uric acid as a promising target for novel therapeutic interventions in the management of type 2 diabetes mellitus and hypertension.
尿酸是循环中嘌呤代谢的最终氧化产物，与痛风和肾结石的发生有关。2 型糖尿病和高血压是两个重要的公共卫生挑战，两者都与心血管事件风险增加有关。高尿酸血症最近通过几种提出的机制成为 2 型糖尿病和高血压发展的独立危险因素。很少有临床试验研究降尿酸药物在这两种疾病实体中的应用；然而，它们的结果提供了令人鼓舞的证据，表明这些药物在对抗疾病负担方面可能发挥作用。因此，需要更大规模的随机对照试验来确定尿酸作为 2 型糖尿病和高血压新型治疗干预的有前途的靶标的作用。
