Lee Seok-Hoon, Kim Kwang-Min, Kim Kyu-Nam
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Republic of Korea.
Medicine (Baltimore). 2017 May;96(19):e6901. doi: 10.1097/MD.0000000000006901.
Gamma-glutamyltransferase (GGT) and uric acid (UA) are novel diabetes risk factors. However, little is known about the combined effects of GGT and UA on the development of diabetes. Here, we assessed the combined effects of GGT and UA on the development of diabetes in a Korean population.We evaluated 1983 women and 2687 men without diabetes. From the baseline health screening to the follow-up examination, the development of diabetes, based on changes in GGT and UA quartile levels, was analyzed. Furthermore, the quartile of GGT and quartile of UA were analyzed together to determine any synergistic effect from the 4th quartile of GGT and UA on the development of diabetes.In women, the development of diabetes gradually increased with an increase in the circulating levels of GGT and UA. For the highest quartile of GGT and UA, hazard ratios of diabetes compared with the lowest quartile were 3.88 (95% confidence interval [CI]: 1.12-13.43, P = .032) and 7.58 (95% CI: 2.17-26.42, P = .002) after adjusting for confounders, respectively. Hazard ratios of diabetes after combining both 4th quartiles of GGT and UA were 5.29 (95% CI: 1.87-15.18, P = .002), as compared with the first and second quartiles. In men, however, the development of diabetes was not significantly different among the quartiles of UA.GGT and UA levels can synergize in predicting the development of diabetes in Korean women.
γ-谷氨酰转移酶（GGT）和尿酸（UA）是新发现的糖尿病风险因素。然而，关于GGT和UA对糖尿病发生发展的联合作用知之甚少。在此，我们评估了GGT和UA对韩国人群糖尿病发生发展的联合作用。我们评估了1983名无糖尿病的女性和2687名无糖尿病的男性。从基线健康筛查到随访检查，基于GGT和UA四分位数水平的变化分析糖尿病的发生情况。此外，将GGT四分位数和UA四分位数一起分析，以确定GGT和UA第四四分位数对糖尿病发生发展的协同作用。在女性中，糖尿病的发生随着GGT和UA循环水平的升高而逐渐增加。对于GGT和UA的最高四分位数，在调整混杂因素后，与最低四分位数相比，糖尿病的风险比分别为3.88（95%置信区间[CI]：1.12 - 13.43，P = 0.032）和7.58（95%CI：2.17 - 26.42，P = 0.002）。与第一和第二四分位数相比，GGT和UA两者的第四四分位数合并后的糖尿病风险比为5.29（95%CI：1.87 - 15.18，P = 0.002）。然而，在男性中，UA四分位数之间糖尿病的发生没有显著差异。GGT和UA水平在预测韩国女性糖尿病发生发展方面具有协同作用。
