Rogers S J, Doyle E, McCulla B A, Lee R M
J Pharm Sci. 1986 Aug;75(8):813-4. doi: 10.1002/jps.2600750819.
A high-performance liquid chromatographic analysis of temelastine in biological fluids with UV detection at 229 nm is presented. The method involves ether extraction followed by re-extraction into phosphoric acid and chromatography on a reversed-phase column. The method has a lower limit of detection of 0.05 mg L-1 and is adequate for use in pharmacokinetic studies following oral administration.
本文介绍了一种采用紫外检测（检测波长为229nm）对生物流体中的替美斯汀进行高效液相色谱分析的方法。该方法包括用乙醚萃取，随后再萃取到磷酸中，并在反相柱上进行色谱分析。该方法的检测下限为0.05mg L-1，适用于口服给药后的药代动力学研究。
