Charles B G, Schneider J J, Norris R L, Ravenscroft P J
Department of Clinical Pharmacology, Princess Alexandria Hospital, Brisbane, Queensland, Australia.
Br J Clin Pharmacol. 1987 Nov;24(5):673-5. doi: 10.1111/j.1365-2125.1987.tb03229.x.
The pharmacokinetics of theophylline (i.v. aminophylline 250 mg) were studied in a balanced, double-blind crossover following the administration of oral temelastine (100 mg) or placebo, twice daily for 7 days, to 10 normal volunteers. Comparison of volumes of distribution, elimination rate constants, elimination half-lives and areas under the plasma concentration-time curve indicated that temelastine had no significant effect on theophylline pharmacokinetics.
在10名正常志愿者中，采用平衡双盲交叉试验，研究了口服替美斯汀（100毫克）或安慰剂，每日两次，共7天之后，静脉注射氨茶碱250毫克时茶碱的药代动力学。分布容积、消除速率常数、消除半衰期以及血浆浓度-时间曲线下面积的比较表明，替美斯汀对茶碱的药代动力学没有显著影响。
