Platenkamp Amy, Mellies Jay L
Biology Department, Reed College, Portland, Oregon, USA.
mSystems. 2017 Jul 25;2(4). doi: 10.1128/mSystems.00049-17. eCollection 2017 Jul-Aug.
Archetypal pathogenic bacterial strains are often used to elucidate regulatory networks of an entire pathovar, which encompasses multiple lineages and phylogroups. With enteropathogenic (EPEC) as a model system, Hazen and colleagues (mSystems 6:e00024-17, 2017, https://doi.org/10.1128/mSystems.00024-17) used 9 isolates representing 8 lineages and 3 phylogroups to find that isolates with similar genomic sequences exhibit similarities in global transcriptomes under conditions of growth in medium that induces virulence gene expression. They also found variation among individual isolates. Their work illustrates the importance of moving beyond observing regulatory phenomena of a limited number of regulons in a few archetypal strains, with the possibility of correlating clinical symptoms to key transcriptional pathways across lineages and phylogroups.
原型致病细菌菌株常被用于阐明整个致病型的调控网络，致病型包含多个谱系和系统发育群。以肠致病性大肠杆菌（EPEC）作为模型系统，黑曾及其同事（《mSystems》6：e00024 - 17，2017年，https://doi.org/10.1128/mSystems.00024 - 17）使用了代表8个谱系和3个系统发育群的9个分离株，发现具有相似基因组序列的分离株在诱导毒力基因表达的培养基中生长条件下，其全局转录组具有相似性。他们还发现了各个分离株之间的差异。他们的工作说明了超越观察少数原型菌株中有限数量调控子的调控现象的重要性，以及将临床症状与跨谱系和系统发育群的关键转录途径相关联的可能性。
