Smith Adrian J, Clutton R Eddie, Lilley Elliot, Hansen Kristine E Aa, Brattelid Trond
1 Norecopa, c/o Norwegian Veterinary Institute, P.O. Box 750, Sentrum, Oslo, Norway.
2 Royal (Dick) School of Veterinary Studies, Easter Bush, Midlothian, UK.
Lab Anim. 2018 Apr;52(2):135-141. doi: 10.1177/0023677217724823. Epub 2017 Aug 3.
There is widespread concern about the quality, reproducibility and translatability of studies involving research animals. Although there are a number of reporting guidelines available, there is very little overarching guidance on how to plan animal experiments, despite the fact that this is the logical place to start ensuring quality. In this paper we present the PREPARE guidelines: Planning Research and Experimental Procedures on Animals: Recommendations for Excellence. PREPARE covers the three broad areas which determine the quality of the preparation for animal studies: formulation, dialogue between scientists and the animal facility, and quality control of the various components in the study. Some topics overlap and the PREPARE checklist should be adapted to suit specific needs, for example in field research. Advice on use of the checklist is available on the Norecopa website, with links to guidelines for animal research and testing, at https://norecopa.no/PREPARE .
涉及实验动物的研究的质量、可重复性和可转化性受到广泛关注。尽管有许多报告指南可供使用，但对于如何规划动物实验却几乎没有总体指导，尽管这是确保质量的逻辑起点。在本文中，我们提出了PREPARE指南：《动物研究与实验程序规划：卓越建议》。PREPARE涵盖了决定动物研究准备质量的三个广泛领域：方案制定、科学家与动物设施之间的沟通以及研究中各个组成部分的质量控制。有些主题相互重叠，PREPARE清单应根据具体需求进行调整，例如在实地研究中。可在Norecopa网站（https://norecopa.no/PREPARE）上获取关于使用该清单的建议，并可链接到动物研究和测试指南。
