脾切除对部分肝切除术后肝脏再生及多胺代谢的影响。

Effect of splenectomy on liver regeneration and polyamine metabolism after partial hepatectomy.

作者信息

Kubo S, Matsui-Yuasa I, Otani S, Morisawa S, Kinoshita H, Sakai K

出版信息

J Surg Res. 1986 Oct;41(4):401-9. doi: 10.1016/0022-4804(86)90054-5.

Abstract

The effect of splenectomy on hepatic ornithine decarboxylase (ODC) induction, DNA synthesis, and mitosis of hepatocytes was studied in rat liver after partial hepatectomy. ODC activity markedly increased in the early stages of liver regeneration, and the increase in the activity was significantly enhanced in splenectomized rats. Splenectomy specifically induced ODC since tyrosine aminotransferase and general protein synthesis were not affected. Splenectomy also enhanced increase in hepatic polyamines, DNA synthesis, and mitosis in regenerating liver. The results suggest that splenectomy affects liver regeneration after partial hepatectomy by enhancing induction of ODC activity, which is an important biochemical event in the early stage of liver regeneration.

摘要

在大鼠部分肝切除术后，研究了脾切除术对肝鸟氨酸脱羧酶（ODC）诱导、DNA合成以及肝细胞有丝分裂的影响。在肝再生早期，ODC活性显著增加，并且在脾切除大鼠中该活性的增加明显增强。由于酪氨酸转氨酶和总蛋白合成未受影响，脾切除术特异性地诱导了ODC。脾切除术还增强了再生肝中肝多胺、DNA合成以及有丝分裂的增加。结果表明，脾切除术通过增强ODC活性的诱导来影响部分肝切除术后的肝再生，而ODC活性诱导是肝再生早期的一个重要生化事件。