α,β-不饱和酮的对映选择性共轭硅氢化反应
Enantioselective conjugate hydrosilylation of α,β-unsaturated ketones.
作者信息
Yang Huan, Weng Guanglin, Fang Dongmei, Peng Changjiang, Zhang Yuanyuan, Zhang Xiaomei, Wang Zhouyu
机构信息
Department of Chemistry, Xihua University Chengdu 610039 China
Chengdu Institute of Biology, Chinese Academy of Sciences Chengdu 610041 China.
出版信息
RSC Adv. 2019 Apr 12;9(21):11627-11633. doi: 10.1039/c9ra01180c.
Abstract
Enantioselective conjugate hydrosilylation of β,β-disubstituted α,β-unsaturated ketones was realized. In the presence of a chiral picolinamide-sulfonate Lewis base catalyst, the reactions provided various chiral ketones bearing a chiral center at the β-position in up to quantitative yields with moderate enantioselectivities.
摘要
实现了β,β-二取代α,β-不饱和酮的对映选择性共轭硅氢化反应。在手性吡啶甲酰胺-磺酸盐路易斯碱催化剂存在下，该反应能以高达定量的产率和中等对映选择性提供各种在β位带有手性中心的手性酮。
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