Rabold Katrin, Netea Mihai G, Adema Gosse J, Netea-Maier Romana T
Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
FEBS Lett. 2017 Oct;591(19):3022-3041. doi: 10.1002/1873-3468.12771. Epub 2017 Aug 11.
Macrophages are innate immune cells that play a role not only in host defense against infections, but also in the pathophysiology of autoimmune and autoinflammatory disorders, as well as cancer. An important feature of macrophages is their high plasticity, with high ability to adapt to environmental changes by adjusting their cellular metabolism and immunological phenotype. Macrophages are one of the most abundant innate immune cells within the tumor microenvironment that have been associated with tumor growth, metastasis, angiogenesis and poor prognosis. In the context of cancer, however, so far little is known about metabolic changes in macrophages, which have been shown to determine functional fate of the cells in other diseases. Here, we review the current knowledge regarding the cellular metabolism of tumor-associated macrophages (TAMs) and discuss its implications for cell function. Understanding the regulation of the cellular metabolism of TAMs may reveal novel therapeutic targets for treatment of malignancies.
巨噬细胞是先天性免疫细胞，不仅在宿主抵御感染中发挥作用，还在自身免疫性和自身炎症性疾病以及癌症的病理生理学中起作用。巨噬细胞的一个重要特征是其高度可塑性，具有通过调节细胞代谢和免疫表型来适应环境变化的高能力。巨噬细胞是肿瘤微环境中最丰富的先天性免疫细胞之一，与肿瘤生长、转移、血管生成和不良预后相关。然而，在癌症背景下，目前对巨噬细胞代谢变化了解甚少，而在其他疾病中已表明代谢变化可决定细胞的功能命运。在此，我们综述了关于肿瘤相关巨噬细胞（TAM）细胞代谢的当前知识，并讨论其对细胞功能的影响。了解TAM细胞代谢的调节可能揭示治疗恶性肿瘤的新治疗靶点。
