Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA.
Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA.
Neuron. 2017 Aug 2;95(3):473-475. doi: 10.1016/j.neuron.2017.07.017.
Unc13 proteins are required for vesicle docking and priming during exocytosis. In this issue of Neuron, Lai et al. (2017) demonstrate that Unc13 ensures that the SNAREs assemble into functional subcomplexes. In a second manuscript, Michelassi et al. (2017) identify a previously unknown autoinhibited state for Unc13 mediated by the tandem C1 and C2 domains.
Unc13 蛋白在囊泡停泊和出胞过程中的起始阶段发挥作用。在本期《神经元》杂志中，Lai 等人（2017）证实 Unc13 可确保 SNARE 组装成功能性亚基。在第二篇论文中，Michelassi 等人（2017）鉴定出 Unc13 由串联的 C1 和 C2 结构域介导的一种未知的自动抑制状态。
