Department of Pharmacology, SVKM's Dr Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai, India.
Department of Pharmacology, SVKM's Dr Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai, India.
Seizure. 2017 Oct;51:27-34. doi: 10.1016/j.seizure.2017.07.014. Epub 2017 Jul 25.
Epilepsy is a common neurological disorder involving recurrent seizures and affecting about 1% of the population worldwide. Despite several antiepileptic drugs and effective therapies available for epilepsy, about 25% of the patients show therapeutic failure. Thus there exists an unmet need for newer antiepileptic drugs targeting newer targets with different mechanisms of action. Current research in epilepsy generally focuses on mechanisms that control neuronal excitability. Recently attention has been focussed on novel targets, their various interactions, and signalling cascades relating to epilepsy. This review summarizes several experimental and clinical findings from literature and explores potential targets which may play crucial role in epilepsy.
癫痫是一种常见的神经系统疾病，涉及反复发作的癫痫发作，影响全球约 1%的人口。尽管有几种抗癫痫药物和有效的治疗方法可用于癫痫，但约 25%的患者治疗失败。因此，需要新型抗癫痫药物针对具有不同作用机制的新靶点。目前的癫痫研究通常集中在控制神经元兴奋性的机制上。最近，人们的注意力集中在与癫痫相关的新靶点、它们的各种相互作用和信号级联上。本综述总结了文献中的一些实验和临床发现，并探讨了可能在癫痫中发挥关键作用的潜在靶点。
