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FePt纳米颗粒的表面改性与热生成

Surface Modification and Heat Generation of FePt Nanoparticles.

作者信息

Wei Da-Hua, Pan Ko-Ying, Tong Sheng-Kai

机构信息

Institute of Manufacturing Technology & Department of Mechanical Engineering, National Taipei University of Technology (TAIPEI TECH), Taipei 10608, Taiwan.

出版信息

Materials (Basel). 2017 Feb 15;10(2):181. doi: 10.3390/ma10020181.

DOI:10.3390/ma10020181
PMID:28772541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5459101/
Abstract

The chemical reduction of ferric acetylacetonate (Fe(acac)₃) and platinum acetylacetonate (Pt(acac)₂) using the polyol solvent of phenyl ether as an agent as well as an effective surfactant has successfully yielded monodispersive FePt nanoparticles (NPs) with a hydrophobic ligand and a size of approximately 3.8 nm. The present FePt NPs synthesized using oleic acid and oleylamine as the stabilizers under identical conditions were achieved with a simple method. The surface modification of FePt NPs by using mercaptoacetic acid (thiol) as a phase transfer reagent through ligand exchange turned the NPs hydrophilic, and the FePt NPs were water-dispersible. The hydrophilic NPs indicated slight agglomeration which was observed by transmission electron microscopy images. The thiol functional group bond to the FePt atoms of the surface was confirmed by Fourier transform infrared spectroscopy (FTIR) spectra. The water-dispersible FePt NPs employed as a heating agent could reach the requirement of biocompatibility and produce a sufficient heat response of 45 °C for magnetically induced hyperthermia in tumor treatment fields.

摘要

使用苯醚多元醇溶剂作为试剂以及有效的表面活性剂，对乙酰丙酮铁（Fe(acac)₃）和乙酰丙酮铂（Pt(acac)₂）进行化学还原，成功制备出具有疏水配体且尺寸约为3.8 nm的单分散FePt纳米颗粒（NPs）。在相同条件下，以油酸和油胺作为稳定剂，采用简单方法合成了目前的FePt NPs。通过使用巯基乙酸（硫醇）作为相转移试剂，通过配体交换对FePt NPs进行表面改性，使纳米颗粒变为亲水性，从而使FePt NPs具有水分散性。通过透射电子显微镜图像观察到亲水性纳米颗粒有轻微团聚现象。傅里叶变换红外光谱（FTIR）证实了表面的硫醇官能团与FePt原子键合。用作加热剂的水分散性FePt NPs能够达到生物相容性要求，并在肿瘤治疗领域的磁诱导热疗中产生45°C的足够热响应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/4ad48ef9101f/materials-10-00181-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/e637e499396b/materials-10-00181-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/e6e084609f1e/materials-10-00181-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/dda8d08edf68/materials-10-00181-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/e576ac0287cf/materials-10-00181-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/c61fdd1dc6bd/materials-10-00181-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/28ba7c67dbf0/materials-10-00181-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/be1458224cf4/materials-10-00181-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/4ad48ef9101f/materials-10-00181-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/e637e499396b/materials-10-00181-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/e6e084609f1e/materials-10-00181-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/dda8d08edf68/materials-10-00181-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/e576ac0287cf/materials-10-00181-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/c61fdd1dc6bd/materials-10-00181-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/28ba7c67dbf0/materials-10-00181-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/be1458224cf4/materials-10-00181-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5459101/4ad48ef9101f/materials-10-00181-g008.jpg

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本文引用的文献

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Hydrophilic Magnetochromatic Nanoparticles with Controllable Sizes and Super-high Magnetization for Visualization of Magnetic Field Intensity.具有可控尺寸和超高磁化强度的亲水性磁变色纳米颗粒用于磁场强度可视化
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