在AZ31镁合金上形成的RGDC肽诱导仿生磷酸钙涂层。
RGDC Peptide-Induced Biomimetic Calcium Phosphate Coating Formed on AZ31 Magnesium Alloy.
作者信息
Cao Lin, Wang Lina, Fan Lingying, Xiao Wenjun, Lin Bingpeng, Xu Yimeng, Liang Jun, Cao Baocheng
机构信息
School of Stomatology, Lanzhou University, Lanzhou 730000, China.
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
出版信息
Materials (Basel). 2017 Mar 28;10(4):358. doi: 10.3390/ma10040358.
Magnesium alloys as biodegradable metal implants have received a lot of interest in biomedical applications. However, magnesium alloys have extremely high corrosion rates a in physiological environment, which have limited their application in the orthopedic field. In this study, calcium phosphate compounds (Ca-P) coating was prepared by arginine-glycine-aspartic acid-cysteine (RGDC) peptide-induced mineralization in 1.5 simulated body fluid (SBF) to improve the corrosion resistance and biocompatibility of the AZ31 magnesium alloys. The adhesion of Ca-P coating to the AZ31 substrates was evaluated by a scratch test. Corrosion resistance and cytocompatibility of the Ca-P coating were investigated. The results showed that the RGDC could effectively promote the nucleation and crystallization of the Ca-P coating and the Ca-P coating had poor adhesion to the AZ31 substrates. The corrosion resistance and biocompatibility of the biomimetic Ca-P coating Mg alloys were greatly improved compared with that of the uncoated sample.
镁合金作为可生物降解的金属植入物在生物医学应用中受到了广泛关注。然而，镁合金在生理环境中的腐蚀速率极高，这限制了它们在骨科领域的应用。在本研究中，通过精氨酸-甘氨酸-天冬氨酸-半胱氨酸（RGDC）肽诱导矿化在1.5倍模拟体液（SBF）中制备磷酸钙化合物（Ca-P）涂层，以提高AZ31镁合金的耐腐蚀性和生物相容性。通过划痕试验评估Ca-P涂层与AZ31基体的附着力。研究了Ca-P涂层的耐腐蚀性和细胞相容性。结果表明，RGDC能有效促进Ca-P涂层的成核和结晶，且Ca-P涂层与AZ31基体的附着力较差。与未涂层样品相比，仿生Ca-P涂层镁合金的耐腐蚀性和生物相容性有了很大提高。
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