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用于混合模式高效液相色谱分离的多孔聚（苯乙烯 - 二乙烯基苯）微球的制备及其用重氮树脂的改性

Preparation of Porous Poly(Styrene-Divinylbenzene) Microspheres and Their Modification with Diazoresin for Mix-Mode HPLC Separations.

作者信息

Yu Bing, Xu Tao, Cong Hailin, Peng Qiaohong, Usman Muhammad

机构信息

Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.

Laboratory for New Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

出版信息

Materials (Basel). 2017 Apr 22;10(4):440. doi: 10.3390/ma10040440.

DOI:10.3390/ma10040440
PMID:28772801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5506891/
Abstract

By using the two-step activated swelling method, monodisperse porous poly(styrene-divinylbenzene) (P(S-DVB)) microparticles were successfully synthesized. The influence of porogens, swelling temperatures and crosslinking agents on the porosity of porous microparticles was carefully investigated. Porous P(S-DVB) microparticles were used as a packing material for high performance liquid chromatography (HPLC). Several benzene analogues were effectively separated in a stainless-steel column as short as 75 mm due to the high specific surface area of the porous microparticles. Porous P(S-DVB) microparticles were further sulfonated and subsequently modified with diazoresin (DR) via electrostatic self-assembly and UV (ultraviolet) radiation. After treatment with UV light, the ionic bonding between sulfonated P(S-DVB) and DR was converted into covalent bonding through a unique photochemistry reaction of DR. Depending on the chemical structure of DR and mobile phase composition, the DR-modified P(S-DVB) stationary phase performed different separation mechanisms, including reversed phase (RP) and hydrophilic interactions. Therefore, baseline separations of benzene analogues and organic acids were achieved by using the DR-modified P(S-DVB) particles as packing materials in HPLC. According to the π-π interactional difference between carbon rings of fullerenes and benzene rings of DR, C and C were also well separated in the HPLC column packed with DR-modified P(S-DVB) particles.

摘要

通过两步活化溶胀法，成功合成了单分散多孔聚（苯乙烯-二乙烯基苯）（P（S-DVB））微粒。仔细研究了致孔剂、溶胀温度和交联剂对多孔微粒孔隙率的影响。多孔P（S-DVB）微粒用作高效液相色谱（HPLC）的填充材料。由于多孔微粒的高比表面积，几种苯类似物在仅75 mm长的不锈钢柱中得到了有效分离。多孔P（S-DVB）微粒进一步磺化，随后通过静电自组装和紫外线（UV）辐射用重氮树脂（DR）进行改性。经紫外线处理后，磺化P（S-DVB）与DR之间的离子键通过DR独特的光化学反应转化为共价键。根据DR的化学结构和流动相组成，DR改性的P（S-DVB）固定相表现出不同的分离机制，包括反相（RP）和亲水相互作用。因此，在HPLC中使用DR改性的P（S-DVB）颗粒作为填充材料实现了苯类似物和有机酸的基线分离。根据富勒烯碳环与DR苯环之间的π-π相互作用差异，C和C在填充有DR改性P（S-DVB）颗粒的HPLC柱中也得到了很好的分离。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733a/5506891/196dbe61f232/materials-10-00440-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733a/5506891/196dbe61f232/materials-10-00440-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733a/5506891/193a14c5fde1/materials-10-00440-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733a/5506891/196dbe61f232/materials-10-00440-g013.jpg

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