对来自乙肝流行地区（塞内加尔）婴儿的乙肝疫苗效力进行的七年研究。
Seven-year study of hepatitis B vaccine efficacy in infants from an endemic area (Senegal).
作者信息
Coursaget P, Yvonnet B, Chotard J, Sarr M, Vincelot P, N'doye R, Diop-Mar I, Chiron J P
出版信息
Lancet. 1986 Nov 15;2(8516):1143-5. doi: 10.1016/s0140-6736(86)90543-x.
A booster dose of hepatitis B vaccine was given to 143 children in whom hepatitis B had not developed 1 year after initial vaccination. Over the next six years the incidence of hepatitis B in this group was 1.5% per year compared with 11.5% per year in a similar group of unvaccinated children. In the first 4 years the protective efficacy of the vaccine was 100%, but during the 5th and 6th years it fell to 67%. For maximum protection a second booster is needed, 5 years after the first.
对143名初次接种疫苗1年后仍未感染乙型肝炎的儿童给予一剂乙型肝炎疫苗加强针。在接下来的六年里，该组儿童乙型肝炎的发病率为每年1.5%，而在一组未接种疫苗的类似儿童中，这一发病率为每年11.5%。在最初4年中，疫苗的保护效力为100%，但在第5年和第6年，这一效力降至67%。为了获得最大程度的保护，需要在首次接种5年后进行第二次加强接种。
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