Santos Madson R E, Fonseca Ana C, Mendonça Patrícia V, Branco Rita, Serra Arménio C, Morais Paula V, Coelho Jorge F J
CEMUC, Department of Chemical Engineering, University of Coimbra, Coimbra 3030-790, Portugal.
CEMUC, Department of Life Sciences, University of Coimbra, Coimbra 3001-401, Portugal.
Materials (Basel). 2016 Jul 20;9(7):599. doi: 10.3390/ma9070599.
Antimicrobial polymers represent a very promising class of therapeutics with unique characteristics for fighting microbial infections. As the classic antibiotics exhibit an increasingly low capacity to effectively act on microorganisms, new solutions must be developed. The importance of this class of materials emerged from the uncontrolled use of antibiotics, which led to the advent of multidrug-resistant microbes, being nowadays one of the most serious public health problems. This review presents a critical discussion of the latest developments involving the use of different classes of antimicrobial polymers. The synthesis pathways used to afford macromolecules with antimicrobial properties, as well as the relationship between the structure and performance of these materials are discussed.
抗菌聚合物是一类非常有前景的治疗剂，具有对抗微生物感染的独特特性。由于经典抗生素对微生物的有效作用能力越来越低，必须开发新的解决方案。这类材料的重要性源于抗生素的无节制使用，这导致了多重耐药微生物的出现，如今这是最严重的公共卫生问题之一。本文综述对使用不同类别的抗菌聚合物的最新进展进行了批判性讨论。讨论了用于制备具有抗菌性能的大分子的合成途径，以及这些材料的结构与性能之间的关系。
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