Sato Takeshi, Uto Koichiro, Aoyagi Takao, Ebara Mitsuhiro
Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Materials (Basel). 2016 Oct 25;9(11):864. doi: 10.3390/ma9110864.
This work describes an intriguing strategy for the creation of arbitrarily shaped hydrogels utilizing a self-healing template (SHT). A SHT was loaded with a photo-crosslinkable monomer, PEG diacrylate (PEGDA), and then ultraviolet light (UV) crosslinked after first shaping. The SHT template was removed by simple washing with water, leaving behind the hydrogel in the desired physical shape. A hierarchical 3D structure such as "Matreshka" boxes were successfully prepared by simply repeating the "self-healing" and "photo-irradiation" processes. We have also explored the potential of the SHT system for the manipulation of cells.
这项工作描述了一种利用自愈合模板(SHT)制备任意形状水凝胶的有趣策略。将光可交联单体聚乙二醇二丙烯酸酯(PEGDA)加载到SHT中,然后在首次成型后用紫外线(UV)交联。通过简单的水洗去除SHT模板,留下所需物理形状的水凝胶。通过简单重复“自愈合”和“光照射”过程,成功制备了诸如“俄罗斯套娃”盒之类的分层三维结构。我们还探索了SHT系统在细胞操控方面的潜力。