吗啡对离体大鼠胃黏膜酸分泌的影响。
The influence of morphine on acid secretion by the isolated rat gastric mucosa.
作者信息
Ho M M, Ogle C W, Dai S
出版信息
Pharmacol Res Commun. 1985 Sep;17(9):855-64. doi: 10.1016/0031-6989(85)90044-x.
PMID:2865752
Abstract
The influence of morphine on acid secretion by the isolated gastric mucosa was studied in adult rats. A wide range of morphine concentrations (1 X 10(-4) to 1.6 X 10(-3) M) was found to have no effect on basal acid output, or on acid secretion maximally stimulated by bethanechol or histamine. It is suggested that the opiate receptors in the rat gastric mucosa, if there are any, are not involved in modulating acid secretion.
摘要
在成年大鼠中研究了吗啡对离体胃黏膜酸分泌的影响。发现一系列广泛的吗啡浓度（1×10⁻⁴至1.6×10⁻³M）对基础酸排出量或对由氨甲酰甲胆碱或组胺最大刺激的酸分泌均无影响。提示大鼠胃黏膜中的阿片受体（如果存在的话）不参与调节酸分泌。
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