Maitrias Pierre, Metzinger-Le Meuth Valérie, Nader Joseph, Reix Thierry, Caus Thierry, Metzinger Laurent
From the Department of Cardiovascular Surgery, Amiens University Hospital, France (P.M., J.N., T.R., T.C.); University Paris 13, Sorbonne Paris Cite, UFR SMBH, Bobigny, France (V.M.-L.M.); INSERM Unit-1088, Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications, Centre Universitaire de Recherche en Santé, University Picardie Jules Verne, Amiens, France (P.M., V.M.-L.M., J.N., T.C., L.M.); Medicine College, Jules Verne University of Picardie, Amiens, France (P.M., T.R.); and Department of Biochemistry, Center of Human Biology, Amiens University Hospital, France (L.M.).
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1608-1617. doi: 10.1161/ATVBAHA.117.309233. Epub 2017 Aug 3.
Cardiovascular disease is the leading cause of morbidity and mortality in developed countries. Stroke is associated with a marked disability burden and has a major economic impact; this is especially true for carotid artery stroke. Major advances in primary and secondary prevention during the last few decades have helped to tackle this public health problem. However, better knowledge of the physiopathology of stroke and its underlying genetic mechanisms is needed to improve diagnosis and therapy. miRNAs are an important, recently identified class of post-transcriptional regulators of gene expression and are known to be involved in cerebrovascular disease. These endogenous, small, noncoding RNAs may have applications as noninvasive biomarkers and therapeutic tools in practice. Here, we review the involvement of several miRNAs in cell-based and whole-animal models of stroke, with a focus on human miRNA profiling studies of carotid artery stroke. Lastly, we describe the miRNAs' potential role as a biomarker of stroke.
心血管疾病是发达国家发病和死亡的主要原因。中风与明显的残疾负担相关，并产生重大经济影响；颈动脉中风尤其如此。过去几十年里，一级和二级预防方面的重大进展有助于应对这一公共卫生问题。然而，需要更好地了解中风的生理病理学及其潜在的遗传机制，以改善诊断和治疗。微小RNA（miRNA）是一类重要的、最近才被发现的基因表达转录后调节因子，已知其与脑血管疾病有关。这些内源性的、小的非编码RNA在实际应用中可能作为非侵入性生物标志物和治疗工具。在这里，我们综述了几种miRNA在中风的细胞模型和整体动物模型中的作用，重点是颈动脉中风的人类miRNA谱研究。最后，我们描述了miRNA作为中风生物标志物的潜在作用。
