青蒿素的微生物转化 由……进行
Microbial transformation of artemisinin by .
作者信息
Yu Hongchang, Zhu Baowu, Zhan Yulian
机构信息
School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, 541004 People's Republic of China.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 People's Republic of China.
出版信息
Bioresour Bioprocess. 2017;4(1):33. doi: 10.1186/s40643-017-0164-6. Epub 2017 Jul 17.
BACKGROUND
Artemisinin () and its derivatives are now being widely used as antimalarial drugs, and they also exhibited good antitumor activities. So there has been much interest in the structural modification of artemisinin and its derivatives because of their effective bioactivities. The microbial transformation is a promising route to obtain artemisinin derivatives. The present study focuses on the microbial transformation of artemisinin by .
RESULTS
During 6 days at 28 °C and 180 rpm, transformed artemisinin to two products. They were identified as 1-deoxyartemisinin () and 4α-hydroxy-1-deoxyartemisinin () on the basis of their spectroscopic data.
CONCLUSIONS
The microbial transformation of artemisinin by was investigated, and two products (1-deoxyartemisinin and 4α-hydroxy-1-deoxyartemisinin) were obtained. This study is the first to report on the microbial transformation of artemisinin by .
背景
青蒿素及其衍生物目前被广泛用作抗疟药物，并且它们还表现出良好的抗肿瘤活性。因此，由于青蒿素及其衍生物具有有效的生物活性，对其进行结构修饰引起了人们的广泛关注。微生物转化是获得青蒿素衍生物的一条有前景的途径。本研究聚焦于[具体微生物]对青蒿素的微生物转化。
结果
在28℃和180转/分钟的条件下培养6天，[具体微生物]将青蒿素转化为两种产物。根据它们的光谱数据，鉴定这两种产物分别为1-脱氧青蒿素和4α-羟基-1-脱氧青蒿素。
结论
研究了[具体微生物]对青蒿素的微生物转化，并获得了两种产物（1-脱氧青蒿素和4α-羟基-1-脱氧青蒿素）。本研究首次报道了[具体微生物]对青蒿素的微生物转化。
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