Choi Kang-Seuk
OIE Reference Laboratory for Newcastle Disease, Avian Disease Research Division, Animal and Plant Quarantine Agency, Gimcheon, Korea.
Clin Exp Vaccine Res. 2017 Jul;6(2):72-82. doi: 10.7774/cevr.2017.6.2.72. Epub 2017 Jul 26.
Recent advances in reverse genetics techniques make it possible to manipulate the genome of RNA viruses such as Newcastle disease virus (NDV). Several NDV vaccine strains have been used as vaccine vectors in poultry, mammals, and humans to express antigens of different pathogens. The safety, immunogenicity, and protective efficacy of these NDV-vectored vaccines have been evaluated in pre-clinical and clinical studies. The vaccines are safe in mammals, humans, and poultry. Bivalent NDV-vectored vaccines against pathogens of economic importance to the poultry industry have been developed. These bivalent vaccines confer solid protective immunity against NDV and other foreign antigens. In most cases, NDV-vectored vaccines induce strong local and systemic immune responses against the target foreign antigen. This review summarizes the development of NDV-vectored vaccines and their potential use as a base for designing other effective vaccines for veterinary and human use.
反向遗传学技术的最新进展使得操纵诸如新城疫病毒（NDV）等RNA病毒的基因组成为可能。几种NDV疫苗株已被用作家禽、哺乳动物和人类的疫苗载体，以表达不同病原体的抗原。这些NDV载体疫苗的安全性、免疫原性和保护效力已在临床前和临床研究中得到评估。这些疫苗在哺乳动物、人类和家禽中都是安全的。已经开发出针对对家禽业具有经济重要性的病原体的二价NDV载体疫苗。这些二价疫苗对NDV和其他外来抗原具有坚实的保护性免疫。在大多数情况下，NDV载体疫苗可诱导针对目标外来抗原的强烈局部和全身免疫反应。本综述总结了NDV载体疫苗的发展及其作为设计其他用于兽医和人类的有效疫苗基础的潜在用途。
