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表达牛暂时热病毒糖蛋白的重组新城疫病毒的特性分析

Characterization of a recombinant Newcastle disease virus expressing the glycoprotein of bovine ephemeral fever virus.

作者信息

Zhang Minmin, Ge Jinying, Wen Zhiyuan, Chen Weiye, Wang Xijun, Liu Renqiang, Bu Zhigao

机构信息

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin, 150001, People's Republic of China.

出版信息

Arch Virol. 2017 Feb;162(2):359-367. doi: 10.1007/s00705-016-3078-2. Epub 2016 Oct 18.

DOI:10.1007/s00705-016-3078-2
PMID:27757685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5306239/
Abstract

Bovine ephemeral fever (BEF) is caused by the arthropod-borne bovine ephemeral fever virus (BEFV), which is a member of the family Rhabdoviridae and the genus Ephemerovirus. BEFV causes an acute febrile infection in cattle and water buffalo. In this study, a recombinant Newcastle disease virus (NDV) expressing the glycoprotein (G) of BEFV (rL-BEFV-G) was constructed, and its biological characteristics in vitro and in vivo, pathogenicity, and immune response in mice and cattle were evaluated. BEFV G enabled NDV to spread from cell to cell. rL-BEFV-G remained nonvirulent in poultry and mice compared with vector LaSota virus. rL-BEFV-G triggered a high titer of neutralizing antibodies against BEFV in mice and cattle. These results suggest that rL-BEFV-G might be a suitable candidate vaccine against BEF.

摘要

牛流行热（BEF）由节肢动物传播的牛流行热病毒（BEFV）引起，BEFV属于弹状病毒科短暂病毒属。BEFV可引起牛和水牛的急性发热感染。在本研究中，构建了一种表达BEFV糖蛋白（G）的重组新城疫病毒（NDV）（rL-BEFV-G），并评估了其在体外和体内的生物学特性、致病性以及在小鼠和牛体内的免疫反应。BEFV G使NDV能够在细胞间传播。与载体LaSota病毒相比，rL-BEFV-G在家禽和小鼠中仍无致病性。rL-BEFV-G在小鼠和牛体内引发了高滴度的抗BEFV中和抗体。这些结果表明，rL-BEFV-G可能是一种合适的抗BEF候选疫苗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e088/5306239/83ba5b7415c5/705_2016_3078_Fig1_HTML.jpg

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