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亲核取代反应的过渡金属催化：S1和S2过程的自由基替代方法

Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S1 and S2 Processes.

作者信息

Fu Gregory C

机构信息

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

出版信息

ACS Cent Sci. 2017 Jul 26;3(7):692-700. doi: 10.1021/acscentsci.7b00212. Epub 2017 Jun 12.

DOI:10.1021/acscentsci.7b00212
PMID:28776010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5532721/
Abstract

Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (S1 and S2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transition-metal complexes provide an attractive approach to addressing these limitations.

摘要

实现烷基亲电试剂亲核取代的经典方法（S1和S2）适用范围有限，通常不适用于采用易于获得的外消旋亲电试剂的对映选择性变体。由手性过渡金属配合物催化的基于自由基的途径为解决这些局限性提供了一种有吸引力的方法。

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