Tang Na, Li Jia-Wei, Liu Yong-Min, Zhong Hua, Wang La-Mei, Deng Feng-Mei, Hui Jing, Qu Yuan-Yuan, He Fang
Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, 832002, Shihezi, China.
Department of Pathology, Medical College of Chengdu University, 610000, Chengdu, China.
Wien Klin Wochenschr. 2017 Oct;129(19-20):709-716. doi: 10.1007/s00508-017-1239-2. Epub 2017 Aug 3.
Human cytomegalovirus (CMV) has been linked to the pathogenesis of elevated arterial blood pressure (BP). Our study aimed to determine the association between anti-CMV titers and arterial BP in the Kazakh and Han Chinese populations.
Kazakh and Han (n = 800 each) (age, ≥18 years) subjects from Xinjiang, China were examined for anti-CMV immunoglobulin (Ig)G titers using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The highest anti-CMV titer tertiles determined within gender and ethnicity groups were compared against the two lower tertiles and seronegative samples.
Multivariate linear regression analysis revealed that anti-CMV titers were independent determinants for elevated systolic (p = 0.006) BP in Kazakh women and inversely associated with systolic (p = 0.004) and mean arterial (p = 0.019) BP in Han women.
The association between CMV infection and/or resulting immune response and BP elevation differed by sex and ethnicity. In Kazakh women, they were associated with elevated BP and the opposite was true among Han women.
人类巨细胞病毒（CMV）与动脉血压（BP）升高的发病机制有关。我们的研究旨在确定哈萨克族和汉族人群中抗CMV滴度与动脉血压之间的关联。
使用市售酶联免疫吸附测定（ELISA）试剂盒对来自中国新疆的哈萨克族和汉族（各800名）受试者（年龄≥18岁）检测抗CMV免疫球蛋白（Ig）G滴度。将性别和种族组内确定的抗CMV滴度最高三分位数与两个较低三分位数和血清阴性样本进行比较。
多变量线性回归分析显示，抗CMV滴度是哈萨克族女性收缩压升高（p = 0.006）的独立决定因素，并且与汉族女性的收缩压（p = 0.004）和平均动脉压（p = 0.019）呈负相关。
CMV感染和/或由此产生的免疫反应与血压升高之间的关联因性别和种族而异。在哈萨克族女性中，它们与血压升高有关，而在汉族女性中则相反。
