Li Zhen, Tang Yan, Tang Na, Feng Qian, Zhong Hua, Liu Yong-Min, Wang La-Mei, He Fang
Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
Department of Emergency and critical care medicine, the First Affiliated Hospital of Medical College of Shihezi University, Shihezi, China.
PLoS One. 2017 Aug 24;12(8):e0181440. doi: 10.1371/journal.pone.0181440. eCollection 2017.
Human cytomegalovirus (CMV) infection is associated with hypertension and has been linked with the pathogenesis of increased arterial blood pressure (BP). Currently, whether CMV infection is associated with the progression of hypertension and hypertensive target organ damage (TOD) remains to be identified. We aimed to examine the relationship between CMV infection and the progression of hypertension and hypertensive TOD, which could provide clues on the possible mediating mechanisms, in the Han Chinese population. A total of 372 patients with hypertension and 191 healthy controls (Han participants from Xinjiang, China) were included in the study. Enzyme-linked immunosorbent assay (ELISA) and qPCR were used to detect CMV infection. C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) titers were also analyzed using an ELISA kit. Moreover, cardiovascular disease markers were evaluated by echocardiography, carotid ultrasonography, and tomographic scans. Essential hypertension (EH) patients exhibited a marked increase in CMV IgG antibody, CRP, TNF-α, and IL-6 levels. Higher grade of hypertension and hypertensive TOD had higher CMV IgG antibody and CRP levels. The CMV IgG antibody titers were positively correlated with arterial BP, greater grade of hypertension and hypertensive TOD, and CRP and IL-6 levels. The higher quartile of CMV IgG titer and CRP level were associated with the incidence of hypertension and the progression of hypertension and hypertensive TOD. In the Han Chinese population, high CMV IgG titers are associated with the progression of hypertension and hypertensive TOD. CMV IgG titer >4.25 U could be an independent predictor of hypertension and progression of hypertension, while that >4.85 U could be an independent risk factor for hypertensive TOD. The underlying mechanism may be largely mediated by chronic inflammation.
人巨细胞病毒（CMV）感染与高血压相关，并与动脉血压（BP）升高的发病机制有关。目前，CMV感染是否与高血压的进展及高血压靶器官损害（TOD）相关仍有待确定。我们旨在研究CMV感染与高血压及高血压性TOD进展之间的关系，这可能为汉族人群中潜在的介导机制提供线索。本研究共纳入372例高血压患者和191名健康对照者（来自中国新疆的汉族参与者）。采用酶联免疫吸附测定（ELISA）和定量聚合酶链反应（qPCR）检测CMV感染。还使用ELISA试剂盒分析C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平。此外，通过超声心动图、颈动脉超声检查和断层扫描评估心血管疾病标志物。原发性高血压（EH）患者的CMV IgG抗体、CRP、TNF-α和IL-6水平显著升高。高血压分级和高血压性TOD越高，CMV IgG抗体和CRP水平越高。CMV IgG抗体滴度与动脉血压、高血压分级和高血压性TOD以及CRP和IL-6水平呈正相关。CMV IgG滴度和CRP水平的较高四分位数与高血压的发生率以及高血压和高血压性TOD的进展相关。在汉族人群中，高CMV IgG滴度与高血压和高血压性TOD的进展相关。CMV IgG滴度>4.25 U可能是高血压及高血压进展的独立预测因子，而>4.85 U可能是高血压性TOD的独立危险因素。潜在机制可能主要由慢性炎症介导。
