Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Chin Med J (Engl). 2017 Aug 20;130(16):1980-1986. doi: 10.4103/0366-6999.211895.
Homocysteine is a sulfur-containing amino acid with potential clinical significance. Abnormal homocysteine levels have been found in patients with psoriasis. This review summarizes the possible correlations among homocysteine, cardiovascular risk, and DNA methylation in psoriasis.
We retrieved the articles published in English from the PubMed database up to January 2017, using the keywords including "psoriasis," "homocysteine," "cardiovascular risk," "DNA methylation," "methylenetetrahydrofolate reductase," "MTHFR," and "MTHFR C677T."
Articles about the roles of homocysteine in the cardiovascular risk and DNA methylation in psoriasis were obtained and reviewed.
Observational studies consistently reported that elevated homocysteine is an independent risk factor for cardiovascular diseases. Several studies also consistently reported an association between psoriasis and increased cardiovascular risk. A substantial body of evidence also suggested that an elevated homocysteine level is related to the demethylation of DNA. Data from clinical trials also demonstrated that MTHFR C677T polymorphisms as well as DNA methylation aberrations are associated with psoriasis.
This review highlighted the relationships among homocysteine, cardiovascular risk, and DNA methylation, suggesting that homocysteine may be a biological link between cardiovascular risk and DNA methylation in psoriasis.
同型半胱氨酸是一种含硫氨基酸,具有潜在的临床意义。银屑病患者存在同型半胱氨酸水平异常。本综述总结了银屑病患者同型半胱氨酸、心血管风险和 DNA 甲基化之间可能存在的相关性。
我们使用包括“银屑病”、“同型半胱氨酸”、“心血管风险”、“DNA 甲基化”、“亚甲基四氢叶酸还原酶”、“MTHFR”和“MTHFR C677T”等关键词,从 PubMed 数据库中检索了截至 2017 年 1 月发表的英文文章,以获取有关同型半胱氨酸在银屑病中对心血管风险和 DNA 甲基化作用的文章,并进行了综述。
获取并综述了有关同型半胱氨酸在银屑病患者心血管风险和 DNA 甲基化中的作用的文章。
观察性研究一致表明,同型半胱氨酸升高是心血管疾病的独立危险因素。几项研究还一致表明银屑病与心血管风险增加之间存在关联。大量证据还表明,同型半胱氨酸水平升高与 DNA 去甲基化有关。临床试验数据还表明,MTHFR C677T 多态性和 DNA 甲基化异常与银屑病有关。
本综述强调了同型半胱氨酸、心血管风险和 DNA 甲基化之间的关系,提示同型半胱氨酸可能是银屑病患者心血管风险和 DNA 甲基化之间的生物学联系。