Ju Yan, Dang Erle, Yang Chunxiang, Song Hongping
Department of Ultrasonography, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Aug 10;34(4):606-610. doi: 10.3760/cma.j.issn.1003-9406.2017.04.030.
Psoriatic arthritis is a form of inflammatory arthritis found among patients with psoriasis, which can lead to pain, swelling or stiffness in one or more joints and even movement disorders. Epidemiological studies have shown a higher heritability for psoriatic arthritis compared with psoriasis vulgaris. With the evolvement of DNA sequencing, many genes have been associated with psoriasis vulgaris and psoriatic arthritis, which included MHC, TNF, LCE, IL23R, IL12B, TRAF3IP2 and TNFAIP3, though some, such as MHC, IL-13 and PTPN22, have been specifically associated with psoriatic arthritis. These studies have laid a foundation for risk prediction, diagnosis and drug development for psoriatic arthritis.
银屑病关节炎是一种在银屑病患者中发现的炎性关节炎，可导致一个或多个关节疼痛、肿胀或僵硬，甚至出现运动障碍。流行病学研究表明，与寻常型银屑病相比，银屑病关节炎的遗传度更高。随着DNA测序技术的发展，许多基因已被发现与寻常型银屑病和银屑病关节炎相关，包括MHC、TNF、LCE、IL23R、IL12B、TRAF3IP2和TNFAIP3，尽管其中一些基因，如MHC、IL - 13和PTPN22，已被明确与银屑病关节炎相关。这些研究为银屑病关节炎的风险预测、诊断和药物研发奠定了基础。
