Department of Medicine, Faculty of Medicine, Memorial University, St. John's, Newfoundland, St. John's, Newfoundland and Labrador, A1B 3X9, Canada.
Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Sci Rep. 2020 Mar 18;10(1):4925. doi: 10.1038/s41598-020-61981-5.
Chronic plaque psoriasis and psoriatic arthritis are multifactorial inter-related diseases with strong genetic contributions. Better elucidation of the heritability of psoriatic disease subsets is important for identifying novel genes, risk stratification and potential clinical applications. In this study, we used two mixed-effect modelling methodologies to assess the additive contribution of common single nucleotide polymorphisms from genome-wide association studies to estimate the heritability of cutaneous psoriasis, psoriasis vulgaris and psoriatic arthritis. We found that cutaneous psoriasis and psoriatic arthritis both exhibit considerable heritability, with a greater contribution coming from cutaneous psoriasis.
慢性斑块状银屑病和银屑病关节炎是多种因素相互关联的疾病，具有强烈的遗传贡献。更好地阐明银屑病疾病亚组的遗传性对于鉴定新基因、风险分层和潜在的临床应用非常重要。在这项研究中，我们使用了两种混合效应建模方法来评估全基因组关联研究中常见的单核苷酸多态性的加性贡献，以估计皮肤银屑病、寻常型银屑病和银屑病关节炎的遗传性。我们发现皮肤银屑病和银屑病关节炎都具有相当大的遗传性，其中皮肤银屑病的贡献更大。
