Heyboer Rd Marvin, Wojcik Susan M, Smith Garrett, Santiago William
Department of Emergency Medicine, Division of Hyperbaric Medicine and Wound Care, Upstate Medical University, Syracuse, New York U.S.
Upstate Medical University, College of Medicine, Syracuse, New York U.S.
Undersea Hyperb Med. 2017 Mar-Apr;44(2):93-99. doi: 10.22462/3.4.2017.2.
Hyperbaric oxygen (HBO₂) therapy is generally safe and well tolerated. However, known side effects do exist. Elevation in the blood pressure of patients undergoing HBO₂ therapy is a less defined potential side effect. We sought to better quantify effects of HBO₂ on blood pressure (BP) in patients undergoing HBO₂.
A retrospective chart review was performed on quality assurance data captured on all patients undergoing HBO₂ between March 2012 and October 2015 at a large tertiary referral university hospital hyperbaric center.
We identified 155 patients who received 3,147 hyperbaric oxygen treatments. For all treatments there was an overall increase in the median systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) following treatment. No statistically significant difference was found when comparing patients with and without hypertension. Calcium channel blockers (CCB) and beta-blockers (BB) were found to have an agonizing effect while ACE inhibitors (ACEI) were found to have a protective effect. The change in SBP was less with each additional treatment in patients undergoing more than one treatment.
The current study demonstrates that absolute rises in blood pressure do occur as a result of HBO₂ therapy. However, the extent of this effect is not large. BB and CCB had agonizing effects while ACEI had a protective effect. Finally, there was a protective effect with more treatments.
高压氧（HBO₂）治疗一般安全且耐受性良好。然而，已知的副作用确实存在。接受HBO₂治疗的患者血压升高是一种定义不太明确的潜在副作用。我们试图更好地量化HBO₂对接受HBO₂治疗患者血压（BP）的影响。
对2012年3月至2015年10月期间在一家大型三级转诊大学医院高压氧中心接受HBO₂治疗的所有患者的质量保证数据进行回顾性图表审查。
我们确定了155名接受3147次高压氧治疗的患者。在所有治疗中，治疗后收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）的中位数总体升高。在比较有高血压和无高血压的患者时，未发现统计学上的显著差异。发现钙通道阻滞剂（CCB）和β受体阻滞剂（BB）有加重作用，而血管紧张素转换酶抑制剂（ACEI）有保护作用。接受不止一次治疗的患者，每次额外治疗后SBP的变化较小。
当前研究表明，HBO₂治疗确实会导致血压绝对升高。然而，这种影响的程度不大。BB和CCB有加重作用，而ACEI有保护作用。最后，多次治疗有保护作用。
