Hutchison V H, Spriestersbach K K
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;85(1):199-206. doi: 10.1016/0742-8413(86)90074-5.
Low doses (0.01, 0.1 mg/kg, i.p.) of histamine (HA) caused selection of significantly lower temperatures, and higher doses (0.5, 1.0 mg/kg) increased temperatures by mudpuppies in linear thermal gradients. Injection of the HA precursor, L-histidine (500 mg/kg) produced an increase in the temperatures selected. Results from injections of HA H1-receptor agonist (2-pyridylethylamine) and antagonist (pyrilamine), and H2-receptor agonist (dimaprit) and antagonist (cimetidine) had significant effects on thermoregulation; H1-receptors may mediate behavioral hyperthermia and H2-receptors behavioral hypothermia. Responses to these histaminic compounds are significantly influenced by the time of day at which the responses are measured and by season and acclimation temperature. The equivalent behavioral responses in both endotherms and ectotherms to agents which produce physiological hyperthermia and hypothermia are probably behavioral hypothermia ("cold seeking") and behavioral hyperthermia ("heat seeking"), respectively.
低剂量（0.01、0.1毫克/千克，腹腔注射）的组胺（HA）会导致泥螈选择显著更低的温度，而高剂量（0.5、1.0毫克/千克）则会使泥螈在线性热梯度中体温升高。注射HA前体L-组氨酸（500毫克/千克）会使选择的体温升高。注射HA H1受体激动剂（2-吡啶乙胺）和拮抗剂（吡苄明）以及H2受体激动剂（二甲双胍）和拮抗剂（西咪替丁）的结果对体温调节有显著影响；H1受体可能介导行为性体温过高，而H2受体介导行为性体温过低。对这些组胺化合物的反应会受到测量反应的一天中的时间、季节和驯化温度的显著影响。恒温动物和变温动物对产生生理性体温过高和过低的药物的等效行为反应可能分别是行为性体温过低（“寻冷”）和行为性体温过高（“寻热”）。
