Nguyen Brenda, Weiss Paul, Beydoun Hind, Kancherla Vijaya
Rollins School of Public Health of Emory University, Atlanta, GA, USA.
Graduate Program in Public Health, Eastern Virginia Medical School, Norfolk, VA, USA.
J Affect Disord. 2017 Dec 1;223:209-217. doi: 10.1016/j.jad.2017.07.019. Epub 2017 Jul 17.
Blood folate concentrations have been linked to an increased risk of depression in adults. Depression is particularly pronounced among women; however, the association between folate concentration and depression is not well-examined among women of reproductive age. The purpose of our study was to assess the association between low serum and red blood cell folate concentration and the risk of moderate to severe depression among non-pregnant women of reproductive age in the United States (U.S.).
We used data from nationally representative, population-based U.S. National Health and Nutrition Examination Survey (NHANES) (2011-2012) examining non-pregnant women of reproductive age (20-44 years). We compared serum and red blood cell (RBC) folate concentrations between women with and without self-reported depression based on Patient Health Questionnaire-9 (PHQ-9) scores, and examined the association between folate concentrations and depression using linear and logistic regression analysis.
A total of 16.7% of eligible women in our study reported to have moderate to severe depression. The median serum folate concentrations for women with and without depression were 17.8ng/ml and 17.2ng/ml, respectively (P = <0.01). There was no statistical difference in median RBC folate concentrations between women with and without depression (P = 0.2). Serum folate concentration was weakly associated with an increased risk of moderate to severe depression among non-pregnant women of reproductive age, after adjusting for important demographic and life-style factors (aOR: 1.11; 95% CI: 1.01, 1.22). There was no interaction with race and ethnicity.
Cross-sectional design.
Folate concentrations in the blood may partly explain the increased risk of moderate to severe depression among non-pregnant women of reproductive age in the U.S. Robust prospective studies are needed to confirm our findings.
血液叶酸浓度与成年人患抑郁症风险增加有关。抑郁症在女性中尤为明显；然而，育龄女性中叶酸浓度与抑郁症之间的关联尚未得到充分研究。我们研究的目的是评估美国育龄非孕妇血清和红细胞叶酸浓度低与中重度抑郁症风险之间的关联。
我们使用了具有全国代表性的美国国家健康与营养检查调查（NHANES）（2011 - 2012年）的数据，该调查针对育龄非孕妇（20 - 44岁）。我们根据患者健康问卷 - 9（PHQ - 9）评分，比较了有和没有自我报告抑郁症的女性之间的血清和红细胞（RBC）叶酸浓度，并使用线性和逻辑回归分析研究叶酸浓度与抑郁症之间的关联。
我们研究中共有16.7%的符合条件女性报告患有中重度抑郁症。有抑郁症和无抑郁症女性的血清叶酸浓度中位数分别为17.8ng/ml和17.2ng/ml（P = <0.01）。有抑郁症和无抑郁症女性的红细胞叶酸浓度中位数无统计学差异（P = 0.2）。在调整重要的人口统计学和生活方式因素后，血清叶酸浓度与育龄非孕妇中重度抑郁症风险增加弱相关（调整后比值比：1.11；95%置信区间：1.01，1.22）。与种族和民族没有交互作用。
横断面设计。
血液中的叶酸浓度可能部分解释了美国育龄非孕妇中重度抑郁症风险增加的原因。需要进行有力的前瞻性研究来证实我们的发现。
