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糖尿病患者的风险分层以及斋月禁食期间钠-葡萄糖协同转运蛋白2抑制剂的作用。

Risk stratification of patients with diabetes and the role of sodium glucose co-transporter inhibitors 2 during Ramadan fasting.

作者信息

Adnan Zaina

机构信息

Internal Medicine, Endocrinology, Diabetes and Metabolism, Clalit Medical Services, Israel.

出版信息

Diabetes Res Clin Pract. 2017 Sep;131:217-218. doi: 10.1016/j.diabres.2017.07.021. Epub 2017 Jul 13.

Abstract

The month of Ramadan represents a golden opportunity for better management of patients with diabetes not only during Ramadan month, but also through the entire year. Pre Ramadan period is crucial for evaluating and preparing patients with diabetes intending to Fast Ramadan. The risk stratification categories should take into consideration patients with diabetes having specific conditions such as nephrotic syndrome who are predisposed to thrombosis independent to their estimated glomerular filtration rate and glycated haemoglobin. Furthermore, population-specific conditions such as nomadic Bedouins living in remote areas should be considered as part of the very high risk category for fasting Ramadan. Published data regarding the use of sodium glucose co-transporter 2 inhibitors during Ramadan is very limited. Dapagliflozin was the only agent studied during Ramadan. Therefore, it is suggested to categorize this group of agents differently from other agents such as metformin and incretin based therapy studied vastly during Ramadan.

摘要

斋月不仅对斋月期间糖尿病患者的更好管理,而且对全年而言都是改善糖尿病患者管理的黄金时机。斋月前时期对于评估和准备打算在斋月期间禁食的糖尿病患者至关重要。风险分层类别应考虑患有特定疾病(如肾病综合征)的糖尿病患者,这些患者易发生血栓形成,与他们的估计肾小球滤过率和糖化血红蛋白无关。此外,特定人群的状况,如生活在偏远地区的游牧贝都因人,应被视为斋月禁食极高风险类别的一部分。关于斋月期间使用钠-葡萄糖协同转运蛋白2抑制剂的已发表数据非常有限。达格列净是斋月期间唯一被研究的药物。因此,建议将这类药物与斋月期间大量研究的其他药物(如二甲双胍和肠促胰岛素疗法)区别分类。

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