1 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
2 Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Aust N Z J Psychiatry. 2018 Jul;52(7):680-689. doi: 10.1177/0004867417720517. Epub 2017 Aug 4.
We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder.
Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor α, C-reactive protein, interleukin 6 and transforming growth factor β1) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined.
A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p = 0.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH211 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -β1.
The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes.
我们研究了与多巴胺能功能相关的醛脱氢酶 2（ALDH2）多态性（rs671）与双相情感障碍患者的细胞因子水平和认知功能变化的相关性，这是一项为期 12 周的随访研究。
招募了首次被诊断为双相情感障碍的患者。在第 0、1、2、4、8 和 12 周检查症状严重程度和血浆细胞因子（肿瘤坏死因子-α、C 反应蛋白、白细胞介素 6 和转化生长因子-β1）水平。在基线和终点评估神经认知功能。确定 ALDH2 多态性基因型。
共招募了 541 例双相情感障碍患者，其中 355 例（65.6%）完成了 12 周的随访。多元线性回归分析显示，ALDH2 多态性与 C 反应蛋白水平的变化之间存在显著关联（p=0.000226）。不同 ALDH2 基因型的患者认知功能的不同方面都有所改善。只有 ALDH211 基因型的患者在认知功能改善与转化生长因子-β1增加之间存在显著相关性。
ALDH2 基因可能影响双相情感障碍患者的细胞因子水平和认知功能变化。此外，细胞因子水平和认知功能的变化仅与特定的 ALDH2 基因型的患者相关。
