Chen Zhicong, He Anbang, Wang Dailian, Liu Yuchen, Huang Weiren
Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Oncotarget. 2017 Feb 21;8(8):14126-14132. doi: 10.18632/oncotarget.12981.
HOXA transcript at the distal tip (HOTTIP), a functional lncRNA transcribed from the 5' tip of the HOXA locus, has been functionally characterized as an oncogene in various cancers. To further explore the clinical value of HOTTIP in cancer, we collected all relevant studies and investigated the association between HOTTIP level and lymph node metastasis (LNM) or overall survival (OS). Literature collection was conducted by searching electronic databases PubMed, Cochrane Library, OVID, Web of Science and Chinese National Knowledge Infrastructure (CNKI)(up to July 7, 2016). Seven studies with 652 cancer patients were included in the meta-analysis according to the inclusion and exclusion criteria. The results showed a significant positive association between HOTTIP levels and LNM (Odds ratio, OR = 2.30, 95 % CI: 1.58-3.35, p < 0.0001) in a fixed-effects model (I2 = 0 %, p = 0.949) and it could also predict poor OS in cancer patients (Hazard ratio HR = 2.24, 95% CI: 1.74-2.90, p < 0.00001) in a fixed-effects model (I2 = 0%, p = 0.925). In conclusion, this meta-analysis demonstrated that the higher expression level of HOTTIP is correlated with positive LNM and poor OS in different types of cancer and HOTTIP might serve as a novel predictor of LNM and survival in human cancer.
HOXA基因座远端转录本（HOTTIP）是一种从HOXA基因座5'端转录的功能性长链非编码RNA（lncRNA），在多种癌症中已被功能性地表征为一种癌基因。为了进一步探究HOTTIP在癌症中的临床价值，我们收集了所有相关研究，并调查了HOTTIP水平与淋巴结转移（LNM）或总生存期（OS）之间的关联。通过检索电子数据库PubMed、Cochrane图书馆、OVID、科学网和中国知网（截至2016年7月7日）进行文献收集。根据纳入和排除标准，7项涉及652例癌症患者的研究被纳入荟萃分析。结果显示，在固定效应模型（I2 = 0%，p = 0.949）中，HOTTIP水平与LNM之间存在显著正相关（优势比，OR = 2.30，95%可信区间：1.58 - 3.35，p < 0.0001），并且在固定效应模型（I2 = 0%，p = 0.925）中它还可以预测癌症患者的不良OS（风险比HR = 2.24，95%可信区间：1.74 - 2.90，p < 0.00001）。总之，这项荟萃分析表明，HOTTIP的高表达水平与不同类型癌症中的阳性LNM和不良OS相关，并且HOTTIP可能作为人类癌症中LNM和生存的一种新型预测指标。
