炎症消退、n-3脂肪酸补充与阿尔茨海默病：一项叙述性综述。

Resolution of inflammation, n-3 fatty acid supplementation and Alzheimer disease: A narrative review.

作者信息

Fraga Vanessa Gomes, Carvalho Maria das Graças, Caramelli Paulo, de Sousa Lirlândia Pires, Gomes Karina Braga

机构信息

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

出版信息

J Neuroimmunol. 2017 Sep 15;310:111-119. doi: 10.1016/j.jneuroim.2017.07.005. Epub 2017 Jul 12.

DOI:10.1016/j.jneuroim.2017.07.005

PMID:28778434

Abstract

In patients with Alzheimer's disease (AD), a persistent and unresolved neuroinflammatory process can contribute to neuronal loss and a decline in their cognitive and functional abilities. Recent studies have demonstrated that the ability to resolve inflammation is impaired in the brains of patients with AD. Preclinical evidence demonstrates the potential of therapeutic interventions on the resolution phase of inflammation in AD. Supplementation of omega-3 fatty acids (n-3 FAs), precursors for specialized pro-resolving mediators, emerged as a possibility for prevention and management of AD. Here, we provide a narrative review of resolving inflammation in AD and the role of n-3 FA supplementation in AD.

摘要

在阿尔茨海默病（AD）患者中，持续且未得到解决的神经炎症过程会导致神经元丧失，并使其认知和功能能力下降。最近的研究表明，AD患者大脑中炎症消退的能力受损。临床前证据表明，针对AD炎症消退阶段进行治疗干预具有潜力。补充ω-3脂肪酸（n-3 FAs）作为特殊促消退介质的前体，成为预防和管理AD的一种可能途径。在此，我们对AD中炎症的消退以及补充n-3 FA在AD中的作用进行叙述性综述。