术中功能性超声脑活动成像。
Intraoperative Functional Ultrasound Imaging of Human Brain Activity.
机构信息
Institut Langevin - Ondes et Images, ESPCI ParisTech, PSL Research University, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France.
Service de neurochirurgie, Groupe Hospitalier Pitié-Salpêtrière, Bâtiment Babinski 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
出版信息
Sci Rep. 2017 Aug 4;7(1):7304. doi: 10.1038/s41598-017-06474-8.
Abstract
The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 µm, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.
摘要
脑活动的功能映射对于进行最佳的胶质瘤手术和最小化术后缺陷风险至关重要。我们引入了一种新的基于功能超声（fUS）的便携式人脑神经影像学模式，用于深部功能皮质映射。使用超快速帧率（1 kHz）的平面波传输，fUS 在手术过程中进行，以测量脑血流的瞬时变化，具有高时空分辨率（250 µm，1 ms）。fUS 在清醒和麻醉患者的脑沟深处，在任务诱发的皮质反应过程中识别、映射和区分大脑激活区域。
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