对氨甲酰甲胆碱（一种直接作用的乙酰胆碱受体激动剂）的急性肌张力障碍反应。

Acute dystonic reaction to bethanechol--a direct acetylcholine receptor agonist.

作者信息

Shafrir Y, Levy Y, Beharab A, Nitzam M, Steinherz R

出版信息

Dev Med Child Neurol. 1986 Oct;28(5):646-8. doi: 10.1111/j.1469-8749.1986.tb03909.x.

DOI:10.1111/j.1469-8749.1986.tb03909.x

Abstract

Bethanechol is a direct agonist of the acetylcholine receptor that was recently introduced in the therapy of gastro-oesophageal reflux. Acute dystonic reactions to bethanechol were observed in a 10-month-old infant who also demonstrated similar dystonic reactions to dopamine receptor blocking agents of two different classes. This first report of acute dystonic reaction to cholinergic agonists in human is in accord with the current theories of the rôle of acetylcholine and dopamine in the pathogenesis of acute dystonic reactions.

摘要

氨甲酰甲胆碱是一种乙酰胆碱受体直接激动剂，最近被用于胃食管反流的治疗。在一名10个月大的婴儿中观察到了对氨甲酰甲胆碱的急性肌张力障碍反应，该婴儿对两种不同类别的多巴胺受体阻滞剂也表现出类似的肌张力障碍反应。这是人类中首次关于胆碱能激动剂急性肌张力障碍反应的报告，与目前关于乙酰胆碱和多巴胺在急性肌张力障碍反应发病机制中的作用的理论相符。