Department of Physical Therapy, Faculty of Health and Medical Sciences, Tokoha University, 1230 Miyakoda, Kita, Hamamatsu, Shizuoka, 431-2102, Japan.
Department of Radiological Technology, Faculty of Health Science, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie, 510-0293, Japan.
Calcif Tissue Int. 2017 Dec;101(6):631-640. doi: 10.1007/s00223-017-0310-3. Epub 2017 Aug 4.
Although it has been recently shown that type 2 diabetics have an increased risk of hip fracture, the effects of exercise therapy to prevent this have not been clarified. We examined whether a treadmill running exercise contributes to the bone mineral density (BMD) and bone microarchitecture of the femur and what kind of exercise intensity and duration are optimum in type 2 diabetes mellitus using KK-Ay diabetic mice. The mice were divided into two running groups, one fast speed and short duration (FS), the other slow speed and long duration (SL), and a group of controls with no running (CO). The running exercise was started when the mice were 8 weeks of age, and continued once a day 5 days per week for 10 weeks. Ten weeks after the start of the running exercise, the BMD of the proximal region and mid-diaphysis in the SL were significantly higher in comparison with that in the CO, whereas there was no difference in bone microarchitecture among the three groups. Blood glucose, insulin levels, and visceral fat contents in the SL were significantly lower than those in the CO and FS. Bone resorption protein and C-reactive protein levels in the SL were significantly lower than those in the CO. These results suggest that slow, long duration loading is better for both bone and glycemic control than fast, short duration loading in type 2 diabetes.
尽管最近有研究表明 2 型糖尿病患者髋部骨折的风险增加，但运动疗法预防这种情况的效果尚未明确。我们使用 KK-Ay 糖尿病小鼠，研究了跑步机跑步运动是否有助于股骨的骨矿物质密度（BMD）和骨微结构，以及 2 型糖尿病中哪种运动强度和持续时间是最佳的。将小鼠分为两组跑步组，一组为快速短时间（FS），另一组为慢速长时间（SL），还有一组无跑步的对照组（CO）。当小鼠 8 周龄时开始进行跑步运动，每周 5 天，每天进行一次，持续 10 周。开始跑步运动 10 周后，与 CO 相比，SL 组股骨近端和骨干中部的 BMD 显著升高，而三组之间的骨微结构没有差异。SL 组的血糖、胰岛素水平和内脏脂肪含量明显低于 CO 和 FS 组。SL 组的骨吸收蛋白和 C 反应蛋白水平明显低于 CO 组。这些结果表明，在 2 型糖尿病中，与快速、短时间的负荷相比，缓慢、长时间的负荷更有利于骨骼和血糖控制。
