Master. Universidade Federal do Mato Grosso do Sul - Faculty of Medicine - Postgraduate Program in Health and Development - Campo Grande (MS), Brazil.
PhD. Universidade Federal do Mato Grosso do Sul - Faculty of Medicine - Postgraduate Program in Health and Development - Campo Grande (MS), Brazil.
Acta Cir Bras. 2022 May 2;37(2):e370207. doi: 10.1590/acb370207. eCollection 2022.
To analyze the effect of high-intensity interval training (HIIT) on bone mineral density (BMD) in a model of type 2 diabetes mellitus.
Thirty-two male, adult, 12-week-old rats (Rattus norvegicus), of the Wistar lineage, were used. The animals induced to the experimental model received a high fat diet for 10 days and, after that period, intraperitoneal injection of streptozotocin (40 mg·kg-1), dissolved in 20 mmol·L-1 sodium citrate solution (pH = 4.5). The experimental group of diabetes was formed by the animals that, 48 h after the injection of streptozotocin, had fasting blood glucose > 250 mg·dL-1). The animals were randomly divided into four groups with eight animals each: HIIT experimental diabetes; HIIT control; sedentary experimental diabetes and sedentary control. The animals in the HIIT group performed an aerobic exercise protocol on a treadmill inclined at an angle of 15° to the horizontal, with interspersed intensity. Five weekly sessions, lasting 49 min each, were held for 6 weeks. The analysis of cortical bone density (CBD) and BMD were performed by X-ray images using the In-Vivo Xtreme II/Bruker system.
For CBD and BMD, when comparing diabetes and control groups, a significant difference was seen between groups in relation to HIIT (p = 0.007). Animals submitted and not submitted to HIIT in the same group showed a significant difference between groups in relation to diabetes (p < 0.001).
The HIIT experimental diabetes group had increased CBD and BMD in comparison with the sedentary experimental diabetes group.
分析高强度间歇训练（HIIT）对 2 型糖尿病模型中骨密度（BMD）的影响。
使用 32 只雄性、成年、12 周龄 Wistar 系大鼠。诱导实验模型的动物接受高脂肪饮食 10 天，在此期间，腹腔注射链脲佐菌素（40mg·kg-1），溶于 20mmol·L-1 柠檬酸钠溶液（pH=4.5）。糖尿病实验组由注射链脲佐菌素后 48 小时空腹血糖>250mg·dL-1的动物组成。动物随机分为四组，每组 8 只：HIIT 实验组糖尿病；HIIT 对照组；久坐实验组糖尿病；久坐对照组。HIIT 组动物在水平倾斜 15°的跑步机上进行有氧运动方案，强度间歇。每周进行 5 次，每次持续 49 分钟，持续 6 周。皮质骨密度（CBD）和 BMD 的分析通过 In-Vivo Xtreme II/Bruker 系统的 X 射线图像进行。
对于 CBD 和 BMD，在糖尿病和对照组之间比较时，HIIT 组之间存在显著差异（p=0.007）。同一组中接受和未接受 HIIT 的动物在糖尿病方面存在组间显著差异（p<0.001）。
与久坐不动的实验组糖尿病相比，HIIT 实验组的 CBD 和 BMD 增加。
