Ott J, Mensink E J, Thompson A, Schot J D, Schuurman R K
Hum Genet. 1986 Nov;74(3):280-3. doi: 10.1007/BF00282549.
In nine family pedigrees in which X-linked agammaglobulinemia (XLA) is segregating, a multi-point linkage analysis has been carried out. In each family, the map distance, d, between XLA and a fixed point in a known map of nine RFLP loci on the X chromosome was estimated by calculating the log likelihoods, L(d). Using a new method, the 10-point likelihood was approximated by appropriately combining three 4-point likelihoods. Homogeneity tests (admixture tests) were performed showing clear evidence for heterogeneity of XLA.
在九个X连锁无丙种球蛋白血症（XLA）正在进行家系分离的家系谱系中，开展了多点连锁分析。在每个家系中，通过计算对数似然值L(d)，估计了XLA与X染色体上九个限制性片段长度多态性（RFLP）位点已知图谱中的一个固定点之间的图距d。使用一种新方法，通过适当地组合三个四点似然值来近似十点似然值。进行了同质性检验（混合检验），结果显示有明确证据表明XLA具有异质性。
