Uemura Y, Kotani S, Yoshimoto S, Fujishita M, Yano S, Ohtsuki Y, Miyoshi I
Jpn J Cancer Res. 1986 Oct;77(10):970-3.
Four female rabbits were given twice-weekly oral inoculation of 2-4 X 10(7) cells from a male rabbit lymphoid cell line persistently infected with human T-cell leukemia virus type I (HTLV-I). After 8 weeks, one of them was found to be seroconverted for HTLV-I. Peripheral lymphocytes from the 4 rabbits were cultured in the presence of T-cell growth factor, and a lymphoid cell line with a normal female karyotype was established only from the seroconverted rabbit. This cell line was reactive with a monoclonal antibody to rabbit T-cells and expressed HTLV-I antigens and virus particles.
给4只雌性兔子每周两次口服接种来自一只持续感染I型人类T细胞白血病病毒（HTLV-I）的雄性兔子淋巴细胞系的2-4×10⁷个细胞。8周后，发现其中一只兔子的HTLV-I血清学发生了转换。将这4只兔子的外周淋巴细胞在T细胞生长因子存在的情况下进行培养，仅从血清学转换的兔子中建立了一个具有正常雌性核型的淋巴细胞系。该细胞系与抗兔T细胞的单克隆抗体发生反应，并表达HTLV-I抗原和病毒颗粒。
