Hirose S, Kotani S, Uemura Y, Fujishita M, Taguchi H, Ohtsuki Y, Miyoshi I
Department of Medicine, Kochi Medical School, Japan.
Virology. 1988 Feb;162(2):487-9. doi: 10.1016/0042-6822(88)90492-8.
The mode of vertical transmission of human T-cell leukemia virus type I (HTLV-I) was investigated by foster-nursing in rabbits. Two of five rabbits born to noninfected mothers and fostered by virus-infected females seroconverted for HTLV-I after 7 weeks, whereas all seven rabbits born to virus-infected mothers and fostered by noninfected females remained seronegative for the observation period of 6 months. Culture of peripheral blood lymphocytes gave rise to an HTLV-I-carrying T-cell line from each of the two seroconverted rabbits. These findings suggest that HTLV-I is transmitted through milk from mother to offspring.
通过在兔子中进行寄养护理来研究人类I型T细胞白血病病毒（HTLV-I）的垂直传播方式。五只由未感染母亲所生并由病毒感染雌性寄养的兔子中，有两只在7周后发生了HTLV-I血清转化，而所有七只由病毒感染母亲所生并由未感染雌性寄养的兔子在6个月的观察期内仍保持血清阴性。对两只血清转化兔子的外周血淋巴细胞进行培养，均产生了携带HTLV-I的T细胞系。这些发现表明，HTLV-I是通过母乳从母亲传播给后代的。
