Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Curr Opin Genet Dev. 2017 Oct;46:132-140. doi: 10.1016/j.gde.2017.07.008. Epub 2017 Aug 2.
Transcription factor-mediated reprogramming has enabled us to induce the fate conversion of somatic cells into other cell types. Although the study of reprogramming mostly occurs at the cellular level in vitro, previous studies have demonstrated that somatic cells are reprogrammable in multicellular organisms too. Recent studies using in vivo reprogramming have provided important insights on regenerative medicine for diseased organs. Moreover, similar studies have revealed unappreciated mechanisms in various biological phenomena, including tissue regeneration, aging, rejuvenation and cancer development in multicellular organisms. Here, we review recent progress and future perspectives of in vivo reprogramming.
转录因子介导的重编程使我们能够诱导体细胞向其他细胞类型的命运转变。尽管重编程的研究主要在体外的细胞水平进行，但之前的研究已经表明，体细胞在多细胞生物中也是可重编程的。最近使用体内重编程的研究为患病器官的再生医学提供了重要的见解。此外，类似的研究揭示了多细胞生物中各种生物学现象（包括组织再生、衰老、 rejuvenation 和癌症发展）中未被重视的机制。在这里，我们回顾了体内重编程的最新进展和未来展望。
