Shantou University Medical College, Shantou 515041, Guangdong Province, China; Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Shantou University Medical College, Shantou 515041, Guangdong Province, China; Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, China.
Biomed Pharmacother. 2017 Oct;94:531-540. doi: 10.1016/j.biopha.2017.07.073. Epub 2017 Aug 3.
Long non-coding RNAs serve as important regulators in complicated cellular activities, including cell differentiation, proliferation and death. Dysregulation of long non-coding RNAs occurs in the formation and progression of cancers. The family of colon cancer associated transcripts, long non-coding RNAs colon cancer associated transcript-1 and colon cancer associated transcript-2 are known as oncogenes involved in various cancers. Colon cancer associated transcript-1 is a novel lncRNA located in 8q24.2, and colon cancer associated transcript-2 maps to the 8q24.21 region encompassing rs6983267. Colon cancer associated transcripts have close associations with clinical characteristics, such as lymph node metastasis, high TNM stage and short overall survival. Knockdown of them can reverse the malignant phenotypes of cancer cells, including proliferation, migration, invasion and apoptosis. Moreover, they can increase the expression level of c-MYC and oncogenic microRNAs via activating a series of complex mechanisms. In brief, the family of colon cancer associated transcripts may serve as potential biomarkers or therapeutic targets for human cancers.
长非编码 RNA 作为重要的调节剂，参与细胞分化、增殖和死亡等复杂的细胞活动。长非编码 RNA 的失调发生在癌症的形成和进展中。结肠癌相关转录物家族，长非编码 RNA 结肠癌相关转录物 1 和结肠癌相关转录物 2，被认为是涉及多种癌症的癌基因。结肠癌相关转录物 1 是一种位于 8q24.2 的新型 lncRNA，而结肠癌相关转录物 2 位于包含 rs6983267 的 8q24.21 区域。结肠癌相关转录物与临床特征密切相关，如淋巴结转移、高 TNM 分期和总生存期短。敲低它们可以逆转癌细胞的恶性表型，包括增殖、迁移、侵袭和凋亡。此外，它们可以通过激活一系列复杂的机制增加 c-MYC 和致癌 microRNA 的表达水平。总之，结肠癌相关转录物家族可能成为人类癌症的潜在生物标志物或治疗靶点。
