长链非编码RNA在肾细胞癌中的作用（综述）
The roles of long non‑coding RNAs in renal cell carcinoma (Review).
作者信息
Su Zhengming, Ao Jian, Zhao Fengjin, Xu Guibin, Chen Huihua, Gao Chen
机构信息
Department of Urology, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China.
Department of General Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China.
出版信息
Mol Clin Oncol. 2022 Nov 28;18(1):4. doi: 10.3892/mco.2022.2600. eCollection 2023 Jan.
Long non-coding RNAs (lncRNAs) are involved in the gene expression regulation and usually play important roles in various human cancers, including the renal cell carcinoma (RCC). Dysregulation of certain lncRNAs are associated with the prognosis of patients with RCC. In the present review, several recently studied lncRNAs were discussed and their critical roles in proliferation, migration, invasion, apoptosis and drug resistance of renal cancer cells were revealed. The research on lncRNAs further increases our understanding on the development and progression of RCC. It is suggested that lncRNAs can be used as biomarkers or therapeutic targets for diagnosis or treatment of renal cancer.
长链非编码RNA（lncRNAs）参与基因表达调控，通常在包括肾细胞癌（RCC）在内的各种人类癌症中发挥重要作用。某些lncRNAs的失调与RCC患者的预后相关。在本综述中，讨论了几种最近研究的lncRNAs，并揭示了它们在肾癌细胞增殖、迁移、侵袭、凋亡和耐药性中的关键作用。对lncRNAs的研究进一步加深了我们对RCC发生发展的理解。建议lncRNAs可作为肾癌诊断或治疗的生物标志物或治疗靶点。
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