Havas T E, Cole P, Parker L, Oprysk D, Ayiomamitis A
J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):856-60. doi: 10.1016/0091-6749(86)90230-7.
A clinical trial was undertaken to assess the effects of oral H1 (diphenhydramine hydrochloride) and H2 (cimetidine) histamine blockade on nasal resistance induced by topical histamine. Ten adult volunteers were tested on two separate occasions. Their noses were pretreated by oral administration of either combined H1 and H2 histamine antagonists or H1 antagonist and placebo. The nasal airflow resistive response to topical histamine was then determined. Combined histamine antagonism was significantly more effective in reducing the nasal resistive response to topical histamine than H1 antagonist alone (p less than 0.0001). Furthermore, ingestion of the oral H1 histamine antagonist, diphenhydramine hydrochloride, alone led to an increase in resistance of the unprovoked nose, whereas combined H1 and H2 antagonism did not lead to a significant change.
进行了一项临床试验，以评估口服H1（盐酸苯海拉明）和H2（西咪替丁）组胺阻滞剂对局部组胺诱导的鼻阻力的影响。十名成年志愿者在两个不同的场合接受了测试。他们的鼻子通过口服联合H1和H2组胺拮抗剂或H1拮抗剂和安慰剂进行预处理。然后测定对局部组胺的鼻气流阻力反应。联合组胺拮抗作用在降低对局部组胺的鼻阻力反应方面比单独使用H1拮抗剂显著更有效（p小于0.0001）。此外，单独摄入口服H1组胺拮抗剂盐酸苯海拉明会导致未激发鼻子的阻力增加，而联合H1和H2拮抗作用不会导致显著变化。
