H1和H2受体阻滞剂对非哮喘受试者组胺诱导的支气管收缩的影响。
Effects of H1- and H2-receptor blocking agents on histamine-induced bronchoconstriction in non-asthmatic subjects.
作者信息
Maconochie J G, Woodings E P, Richards D A
出版信息
Br J Clin Pharmacol. 1979 Mar;7(3):231-6. doi: 10.1111/j.1365-2125.1979.tb00927.x.
Abstract
1 Two studies have been carried out to investigate the effect of H1- and H2-receptor blocking agents on histamine-induced bronchoconstriction in non-asthmatic subjects. 2 The H2-receptor blocker cimetidine administered orally had no effect on histamine-induced bronchoconstriction on any of the subjects tested. In three of four subjects, the H1-receptor blocker, chlorpheniramine given orally, inhibited the effect of the histamine in the lung. 3 The effects of intravenous chlorpheniramine and cimetidine, both alone and in combination, upon histamine-induced bronchoconstriction, were also studied. Chlorpheniramine inhibited the effect of the histamine and this was significantly dose related. This was not so with cimetidine and there was no evidence that the dose response curve to chlorpheniramine was affected by the additional administration of cimetidine. 4 The results show that histamine-induced bronchoconstriction in non-asthmatic subjects is not mediated by H2-receptors, but it is likely that H1-receptors are involved.
摘要
- 已经开展了两项研究，以调查H1和H2受体阻断剂对非哮喘受试者组胺诱导的支气管收缩的影响。2. 口服给予H2受体阻断剂西咪替丁，对任何受试对象的组胺诱导的支气管收缩均无影响。在四名受试对象中的三名中，口服给予H1受体阻断剂氯苯那敏可抑制组胺在肺部的作用。3. 还研究了静脉注射氯苯那敏和西咪替丁单独及联合使用对组胺诱导的支气管收缩的影响。氯苯那敏抑制组胺的作用，且这与剂量显著相关。西咪替丁则不然，没有证据表明西咪替丁的额外给药会影响氯苯那敏的剂量反应曲线。4. 结果表明，非哮喘受试者中组胺诱导的支气管收缩不是由H2受体介导的，但H1受体可能参与其中。
相似文献
1
Effects of H1- and H2-receptor blocking agents on histamine-induced bronchoconstriction in non-asthmatic subjects.H1和H2受体阻滞剂对非哮喘受试者组胺诱导的支气管收缩的影响。
Br J Clin Pharmacol. 1979 Mar;7(3):231-6. doi: 10.1111/j.1365-2125.1979.tb00927.x.
2
The effects of H1 and H2 antihistamines on histamine inhalation challenges in asthmatic patients.H1和H2抗组胺药对哮喘患者组胺吸入激发试验的影响。
Am Rev Respir Dis. 1979 Dec;120(6):1251-8. doi: 10.1164/arrd.1979.120.6.1251.
3
A comparison of the actions of H1 and H2 antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients.H1和H2抗组胺药对哮喘患者组胺诱导的支气管收缩和皮肤风团反应作用的比较。
J Allergy Clin Immunol. 1981 Mar;67(3):171-7. doi: 10.1016/0091-6749(81)90057-9.
4
Factors modulating the interindividual variability of airway responsiveness to histamine. The influence of H1 and H2 receptors.调节气道对组胺反应性个体差异的因素。H1和H2受体的影响。
Bull Eur Physiopathol Respir. 1981;17(5):807-21.
5
Involvement of histamine H1- and H2-receptors in induced asthmas in dogs.组胺H1和H2受体在犬诱发哮喘中的作用。
Jpn J Pharmacol. 1977 Dec;27(6):791-7. doi: 10.1254/jjp.27.791.
6
The role of histamine receptors in asthma.组胺受体在哮喘中的作用。
Clin Sci (Lond). 1981 Apr;60(4):363-70. doi: 10.1042/cs0600363.
7
Effect of inhaled H1 and H2 receptor antagonist in normal and asthmatic subjects.吸入性H1和H2受体拮抗剂对正常人和哮喘患者的作用。
Thorax. 1980 Jun;35(6):428-34. doi: 10.1136/thx.35.6.428.
8
The effects of H1 and H2 receptor antagonism on the response of monkey skin to intradermal histamine, reverse-type anaphylaxis, and passive cutaneous anaphylaxis.H1和H2受体拮抗作用对猴皮肤对皮内组胺反应、反向型过敏反应及被动皮肤过敏反应的影响。
J Allergy Clin Immunol. 1979 Jun;63(6):376-82. doi: 10.1016/0091-6749(79)90209-4.
9
Histamine receptor blocking effects of cimetidine in the airways.西咪替丁在气道中的组胺受体阻断作用。
Agents Actions. 1983 Feb;13(1):16-20. doi: 10.1007/BF01994276.
10
Histamine blocking agents in healthy and asthmatic subjects.健康受试者和哮喘患者体内的组胺阻断剂
Chest. 1982 Aug;82(2):143-7. doi: 10.1378/chest.82.2.143.
引用本文的文献
1
Histamine-induced cytosolic calcium mobilization in human bronchial smooth muscle cells.组胺诱导人支气管平滑肌细胞胞质钙动员
J Smooth Muscle Res. 2025;61:29-42. doi: 10.1540/jsmr.61.29.
2
A novel model of IgE-mediated passive pulmonary anaphylaxis in rats.一种新型的大鼠IgE介导的被动性肺过敏反应模型。
PLoS One. 2014 Dec 26;9(12):e116166. doi: 10.1371/journal.pone.0116166. eCollection 2014.
3
Relaxation of human isolated bronchial smooth muscle. Role of prostacyclin and prostaglandin F2 alpha in muscle tone.人离体支气管平滑肌的舒张。前列环素和前列腺素F2α在肌张力中的作用。
Lung. 1981;159(3):153-61. doi: 10.1007/BF02713911.
4
Relationship between asthma and gastro-oesophageal reflux.哮喘与胃食管反流之间的关系。
Thorax. 1981 Feb;36(2):116-21. doi: 10.1136/thx.36.2.116.
5
Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development.豚鼠气道在发育过程中体内和体外对西咪替丁和普萘洛尔反应的变化。
Br J Pharmacol. 1982 Mar;75(3):531-7. doi: 10.1111/j.1476-5381.1982.tb09170.x.
6
Histamine receptor blocking effects of cimetidine in the airways.西咪替丁在气道中的组胺受体阻断作用。
Agents Actions. 1983 Feb;13(1):16-20. doi: 10.1007/BF01994276.
7
H1-receptor antagonists: comparative pharmacology and clinical use.H1受体拮抗剂：比较药理学与临床应用
Klin Wochenschr. 1982 Sep 1;60(17):983-90. doi: 10.1007/BF01716959.
8
The response of cat airways to histamine in vivo and in vitro.猫气道在体内和体外对组胺的反应。
Br J Pharmacol. 1985 Feb;84(2):309-16. doi: 10.1111/j.1476-5381.1985.tb12915.x.
本文引用的文献
1
The role of atropine as a mediator blocker of induced bronchial obstruction.阿托品作为诱导性支气管阻塞介质阻滞剂的作用。
J Allergy. 1970 Mar;45(3):178-86. doi: 10.1016/0021-8707(70)90126-7.
2
The pharmacology of azatadine, a potential antiallergy drug.氮他定（一种潜在的抗过敏药物）的药理学
Agents Actions. 1974 Oct;4(4):264-70. doi: 10.1007/BF01965229.
3
A vasodepressor action of histamine mediated by H2-receptor activation.由H2受体激活介导的组胺血管减压作用。
Eur J Pharmacol. 1974 Nov;29(1):10-4. doi: 10.1016/0014-2999(74)90163-0.
4
Histamine H2-receptors in the sheep bronchus and cat trachea: the action of burimamide.绵羊支气管和猫气管中的组胺H2受体：布立马胺的作用
Br J Pharmacol. 1973 Jun;48(2):321-3. doi: 10.1111/j.1476-5381.1973.tb06920.x.
5
Inhibition of histamine release by histamine controlled by H2 receptor.由H2受体控制的组胺对组胺释放的抑制作用。
Nature. 1973 Aug 3;244(5414):287-8. doi: 10.1038/244287a0.
6
An analysis of the depressor responses to histamine in the cat and dog: involvement of both H1- and H2-receptors.猫和狗对组胺降压反应的分析：H1和H2受体均参与其中。
Br J Pharmacol. 1975 Jul;54(3):319-24. doi: 10.1111/j.1476-5381.1975.tb07571.x.
7
Vascular reactions to histamine and compound 48/80 in human skin: suppression by a histamine H2-receptor blocking agent.组胺和48/80对人体皮肤的血管反应：组胺H2受体阻断剂的抑制作用
Br J Clin Pharmacol. 1977 Jun;4(3):367-9. doi: 10.1111/j.1365-2125.1977.tb00725.x.
8
Effects of labetalol and propranolol on histamine-induced bronchoconstriction in normal subjects.拉贝洛尔和普萘洛尔对正常受试者组胺诱导的支气管收缩的影响。
Br J Clin Pharmacol. 1977 Apr;4(2):157-62. doi: 10.1111/j.1365-2125.1977.tb00688.x.
9
10
Further studies on the mechanism of human histamine-induced asthma: the effect of an aerosolized H1 receptor antagonist (diphenhydramine).关于人组胺诱导哮喘机制的进一步研究：雾化H1受体拮抗剂（苯海拉明）的作用
J Allergy Clin Immunol. 1977 Jun;59(6):420-4. doi: 10.1016/0091-6749(77)90004-5.
Zotero 插件