Wood-Baker R, Lau L, Howarth P H
University Medicine, Southampton General Hospital, UK.
Clin Otolaryngol Allied Sci. 1996 Aug;21(4):348-52. doi: 10.1111/j.1365-2273.1996.tb01085.x.
The aim was to determine the effect of H1- and H2-receptor blockade on histamine-induced changes in nasal airways resistance and lavage protein concentrations. Normal subjects were pretreated with oral cetirizine or ranitidine in a double-blind and randomized manner. Measurements of the concentration of total protein and albumin in nasal lavage fluid together with nasal airway resistance were made before and after challenge. Any effect of treatment was assessed by comparing the areas under the time-response curves. In all nine subjects available for analysis histamine caused an immediate increase in all measurements. Ranitidine reduced the maximum increase in nasal airway resistance, but this effect was significant only in combination with certirizine. The increase in lavage total protein and albumin concentrations was almost completely abolished by cetirizine, whereas ranitidine had less effect. We conclude that the histamine H1-receptor has the greatest effect on changes in nasal vascular permeability induced by topical histamine, whereas the H2-receptor has the greatest effect on nasal obstruction.
目的是确定H1和H2受体阻滞剂对组胺诱导的鼻气道阻力和灌洗蛋白浓度变化的影响。正常受试者以双盲和随机方式口服西替利嗪或雷尼替丁进行预处理。在激发前后测量鼻灌洗液中总蛋白和白蛋白的浓度以及鼻气道阻力。通过比较时间-反应曲线下的面积来评估治疗的任何效果。在所有可用于分析的9名受试者中，组胺导致所有测量值立即增加。雷尼替丁降低了鼻气道阻力的最大增加，但这种效果仅在与西替利嗪联合使用时才显著。西替利嗪几乎完全消除了灌洗总蛋白和白蛋白浓度的增加，而雷尼替丁的作用较小。我们得出结论，组胺H1受体对局部组胺诱导的鼻血管通透性变化影响最大，而H2受体对鼻阻塞影响最大。
