Jakobsen C J, Grabe N, Nielsen E, Højbjerg T, Damm M, Lorentzen K, Ersgaard H V, Villadsen J, Heebøl-Holm B, Madsen J I
J Hosp Infect. 1986 Nov;8(3):217-23. doi: 10.1016/0195-6701(86)90116-7.
Intravenous administration sets were changed at varying time intervals between every 24 h and 120 h in 387 patients. The rates of intraluminal contamination of the cannulae and of local inflammation were measured in relation to the time interval between changing sets. There was no correlation between phlebitis and intraluminal contamination, but a significant association was found between phlebitis and fever, infusion of potassium at greater than 10 mmol l-1, Venflon type 140 and infusion of blood or intralipid. No correlation was found between septicaemia and intraluminal contamination of the infusion systems. Contamination of cannulae increased slightly with time, but this was not statistically significant. We conclude that there will be no clinical benefit by daily changing of administration sets, compared with changing up to every fifth day.
387例患者静脉给药装置的更换时间间隔在每24小时至120小时之间不等。根据更换装置的时间间隔，测定了套管腔内污染率和局部炎症发生率。静脉炎与管腔内污染之间无相关性，但发现静脉炎与发热、输注钾浓度大于10 mmol/L、140型静脉留置针、输注血液或脂肪乳之间存在显著关联。败血症与输液系统管腔内污染之间无相关性。套管污染随时间略有增加，但无统计学意义。我们得出结论，与每五天更换一次相比，每天更换给药装置并无临床益处。
